COX-2 Blockade in Cancer Prevention and Therapy (Cancer Drug by Randall E. Harris

By Randall E. Harris

The revelation that aspirin and aspirin-like compounds have notableantineo­ plastic homes has revolutionized melanoma study. COX-2 Blockade in melanoma Prevention and treatment chronicles the proof and provides fascinating new op­ portunities for using cyclooxygenase-2 (COX-2) blockade within the prevention and remedy of melanoma. The textual content is split greatly into 5 components. First, an ancient evaluate records the medical discovery ofCOX-2 and the pharma­ ceutical improvement of nonsteroidal anti inflammatory medicinal drugs (NSAIDs) designed for selective COX-2 inhibition. the method in which crucial poly­ unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and melanoma improvement, and its interruption by way of COX-2 inhibition, is elucidated. this is often through a bit at the epidemiology of NSAIDs and cancers of the colon and breast, and different anatomic websites. those chapters replicate major melanoma defense due to the average use of universal NSAIDs comparable to aspirin and ibuprofen. a bit on animal types of carcinogenesis provides finished proof that basic NSAIDs inhibit quite a few malignant neoplasms in vivo, and highlights contemporary findings which express that COX-2 blockading brokers produce notable chemopreventive results opposed to colon melanoma and breast melanoma in addition to different malignancies. Genetic types are awarded confirming the serious function of COX-2 in carcinogenesis. part IV then discusses the molecular biology of COX -2 vis-a-vis the position of COX -2 and, to a lesser quantity, COX -1, in modulating a couple of very important tactics in molecular carcinogenesis comparable to mutagen­ esis, mobile department, angiogenesis, mobilephone differentiation, and apoptosis.

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