By Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro
This authoritative quantity offers a holistic photograph of antibody-drug conjugates (ADCs). Fourteen complete chapters are divided into six sections together with an creation to ADCs, the ADC build, improvement matters, panorama, IP and pharmacoeconomics, case reviews, and the way forward for the sector. The booklet examines every thing from the choice of the antibody, the drug, and the linker to a dialogue of developmental matters resembling formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory demanding situations. It additionally explores pharmacoecomonics and highbrow homes, together with lately issued patents and the associated fee research of drug treatment. Case reports are awarded for the 3 ADCs that experience got FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), in addition to an ADC in late-stage scientific trials, glembatumumab vedotin (CDX-011). eventually, the quantity offers a viewpoint via the editors at the destiny instructions of ADC improvement and medical purposes. Antibody-Drug Conjugates is a pragmatic and systematic source for scientists, professors, and scholars attracted to increasing their wisdom of state of the art examine during this fascinating field.
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